Comparison of Ethiodol Contrast Media with Iodinated Microspheres for Use in 1000 Fps High-Speed Angiography (HSA) to Determine Blood Flow Details and Blood Velocity
X Wu*, A Shields, S Setlur Nagesh, D Bednarek, S Rudin, University at Buffalo (SUNY) School of Medicine, Buffalo, NY
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MO-IePD-TRACK 1-7 (Monday, 7/26/2021) 12:30 PM - 1:00 PM [Eastern Time (GMT-4)]
Purpose: To compare the performance of Ethiodol, a non-water-soluble iodinated contrast agent, with iodinated microspheres in obtaining blood velocity distributions in order to achieve accurate blood flow evaluations important for diagnosis and outcome predictions in vascular disease.
Methods: A 3D-printed patient-specific basilar bifurcation aneurysm phantom was placed in a constant flow loop, with a flow rate of 315 mL/min as measured at the phantom inlet. For each contrast media, 1500 images were acquired at 70 kV, 100 mA, and 1000 fps using the Actaeon photon counting detector (PCD), which has 100 micron pixel pitch. The respective contrast media were injected using an automated syringe pump through a 4 Fr catheter at a fixed rate of 60 mL/min. 1 mL of Ethiodol and 0.5 mL of 700-900 micrometer diameter iodine-coated microspheres were injected. The Ethiodol stream breaks up into droplets of similar size to that of the microspheres upon injection. X-ray Particle Image Velocimetry (XPIV) was performed using an automated particle tracking algorithm to obtain velocity distributions from the 1000 fps HSA sequences, which were then compared with each other. Contrast-to-noise ratios (CNR) of the two methods were evaluated for 10 different samples of tracked microspheres and 10 different samples of tracked Ethiodol droplets.
Results: Similar velocity distributions were obtained around the aneurysm sac ROI for the Ethiodol and microspheres. The average CNR was 4.96 for the Ethiodol and 2.78 CNR for the iodinated microspheres.
Conclusion: This work indicates that Ethiodol XPIV produces comparable velocity information to iodinated-microsphere XPIV for in-vitro applications. The Ethiodol droplets also produce a higher CNR than the iodinated microspheres, indicating a smaller radiation dose could be used for its particle tracking capability.
Funding Support, Disclosures, and Conflict of Interest: Supported by NIH Grant 1R01EB030092.
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