Assessment of Magneto-Plasmonic Nanoparticles as a Theragnostic for MRI-Based Photothermal Therapy: A Numerical 3-D Modeling Study in Mice
zahed tavangari - Iran university of medical sciences
Presentations
PO-GePV-M-55 (Sunday, 7/25/2021) [Eastern Time (GMT-4)]
Purpose: to present a three-dimensional photothermal therapy, finite element method based model in mice. which is developed to estimate temperature elevations of tumor due to notable optical absorption of magneto-plasmonic Nano particles imbedded in the tumor bearing mice.
Methods: In our modelling, mice (male BALB/c, 18g weight) Geometry was acquired with Magnetic Resonance Imaging (MRI) and used slicer software for segment nanoparticle distribution. the wavelength of irradiated laser was 808nm and the size of nanoparticles was 40-70 nm.
Results: the temperature elevation for 5 min was about 51 Celsius degree which is very promising result for this dual modality nanoparticle.
Conclusion: Given this knowledge, controlling these parameters in photothermal treatment playing a key role:1. 3D in vivo visualization help us to selective targeting,2. The intensity of irradiated leaser,3. The importance of aspect ratio 4.Correlation between nanoparticles volume fraction Overall, we found a good agreement between the experimental data and numerical modelling, obviously these agreements open new doors for further research in photo thermal therapy and enhanced models.
ePosters
Keywords
Contrast Agent, Optical Modeling, Thermal Ablation
Taxonomy
TH- Non-Ionizing Radiation Therapies: Laser Thermal Therapy
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