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Keywords: radiobiology
MO-IePD-TRACK 5-7Principal Component Analysis of Dose Clustering Patterns for Parotid Toxicity Modeling in Head and Neck Radiation Therapy
M Chao1*, I El Naqa2, Y Lo1, J Penagaricano2, (1) Mount Sinai Medical Center, New York, NY, (2) Moffitt Cancer Center, Tampa, FL
PO-GePV-M-222Direct Proton Dosimetry for Fractionated Radiotherapy: Dose Invariance Features and Mono-Endpoints
K Wang1*, R Beatty2, (1) UPMC Hillman Cancer Center, Pittsburgh, PA, (2) M.S. Hershey Medical Center, Hershey, PA
PO-GePV-T-94Novel Collimator for High-Throughput Proton FLASH-RT Murine Hemithorax Irradiations
S Mossahebi, Y Poirier*, A Gerry, C Repetto, Z Vujaskovic, I Jackson, A Sawant, University of Maryland School of Medicine, Baltimore, MD
PO-GePV-T-434Investigate Depth-Dependent Dose Enhancement of PSMA-Targeted Gold Nanoparticles Assisted Radiosensitization at Megavoltage Energy
D Hara*, J Shi, R Schmidt, W Tao, W Ma, N Dogan, J Ford, A Pollack, University of Miami, Miami, FL,
PO-GePV-T-437Precise Pulse Delivery Control Using Monitor Units in Electron FLASH-RT
J Xu*, Y Poirier, A Sawant, University of Maryland School of Medicine, Baltimore, MD
PO-GePV-T-440Radiation Cell Survival Fraction After a FLASH Radiation Pulse
S Zhou1*, Y Yan1, D Zheng1, S Wang1, S Wisnoskie1, D Umstadter2, (1) University of Nebraska Medical Center, Omaha, NE, (2) University Of Nebraska-Lincoln, Lincoln, NE
PO-GePV-T-441A Study of Indirect Apoptotic Death by Vascular Damage On Cell Survival After Single-Fraction Radiotherapy by Using An Improved Cellular Automata Model
D Kawahara1*, L WU2, Y Nagata1, Y Watanabe2, (1) ,Hiroshima University, Hiroshima, JP, (2) Minnesota University, Minneapolis, MN
PO-GePV-T-445Relative Response of Murine Lung Tumors From Conventional Radiotherapy (CRT) Versus Pulsed Low-Dose-Rate (PLDR) Radiotherapy
T Dos Santos*, D Cvetkovic, L Chen, C Ma, Fox Chase Cancer Center, Philadelphia, PA
TU-AB-TRACK 5-0Radiation as a Biological Rather Than a Physical Tool to Combat Cancer
A McNamara1*, J Eley2*, S Bright3*, W Ngwa4*, (1) Mass General Hospital and Harvard Medical School, Boston, MA, (2) Vanderbilt University School of Medicine, Nashville, TN, (3) UT MD Anderson Cancer Center, Houston, TX, (4) Brigham and Women's Hospital, Boston, MA
TU-C-TRACK 6-2DNA Repair Inhibitors Combined with Protons Increase Cell Radiosensitivity in Vitro
D Flint*, S Bright, B Turner, M Manandhar, M Ben Kacem, S Shaitelman, G Sawakuchi, UT MD Anderson Cancer Center, Houston, TX
TU-C-TRACK 6-3Features Of TOPAS-NBio – Release 1.0 
J Schuemann1*, A McNamara1, J Ramos-Mendez2, N Dominguez-Kondo3, J Perl4, D Yoo1, N Henthron5, J Warmenhoven5, S Ingram5, M Merchant5, K Kirkby5, K Held1, J Laverne5, H Paganetti1, B Faddegon2, (1) Physics Division, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA, Boston, MA, (2) University of California San Francisco, San Francisco, CA, (3) Benemerita Universidad Autonoma de Puebla, Puebla, Mexico, (4) Stanford Linear Accelerator Center, Menlo Park, CA, (5) Division of Cancer Sciences, Faculty of Biology, Medicine and Health, The University of Manchester and The Christie NHS Foundation Trust, Manchester, United Kingdom, GB, (6) The University of Notre Dame, Notre Dame, IN
TU-C-TRACK 6-6Potential Anti-Kras Activity OfFlavonoid Derivative of Cannabis Is Enhanced by a Single Fraction of Low Doseof Radiation Therapy
S Yasmin-Karim1*, M Moreau2, N Bih3, N Toyang4, W Ngwa5, (1) Harvard Medical School,Boston, MA, (2) Dana Farber Cancer Institute, Everett, MA, (3) Dana Farber Cancer Institute, Boston, MA, (4) Flavocure Biotech LLC, Baltimore, MD, (5) Brigham and Womens Hospital, Boston, MA
TU-D-TRACK 6-1ATR Inhibition Suppresses DNA Damage Signaling and Sensitizes Cancer Cells to Photons and Protons
D Martinus*, S Bright, D Flint, B Turner, M Manandhar, M Ben Kacem, S Shaitelman, G Sawakuchi, UT MD Anderson Cancer Center, Houston, TX
TU-D-TRACK 6-2Modeling DNA Structure with Different Chromatin Compaction in TOPAS-NBio Using Hi-C Representations
D Yoo1*, N Henthron2, S Ingram2, M Merchant2, K Kirkby2, J Warmenhoven2, A McNamara1, K Held1, H Paganetti1, J Schuemann1, (1) Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA (2) Division Of Cancer Sciences, Faculty Of Biology, Medicine and Health, The University of Manchester and The Christie NHS Foundation Trust, Manchester, United Kingdom
TU-E-TRACK 5-2Analysis of Proton Inter-Track Interactions at Ultra-High Dose Rates
S Thompson*, K Prise, S McMahon, Queen's University Belfast, Belfast, GB
TU-E-TRACK 5-3BEST IN PHYSICS (THERAPY): FLASH Sparing of Normal Tissue in a Proton Spread Out Bragg Peak
M Kim*, I Verginadis, A Haertter, D Goia, K Shoniyozov, J Zou, C Koumenis, J Metz, K Cengel, L Dong, E Diffenderfer, University of Pennsylvania, Philadelphia, PA
TU-E-TRACK 5-4Measuring Oxygen Concentration at Ultra-Fast Rates During Proton FLASH Delivery Using Phosphorescence Quenching of Soluble Oxyphor Probes
A L Van Slyke*, M El Khatib, K Shoniyozov, E Diffenderfer, M Kim, C J Koch, S A Vinogradov, R D Wiersma, University of Pennsylvania, Philadelphia, PA
WE-A-TRACK 6-5The Relative Variability in Radiosensitivity Between Cell Lines Is the Same for Carbon Ions, Protons and X-Rays
D Flint*, S Bright, B Turner, M Manandhar, M Ben Kacem, D Martinus, S Shaitelman, G Sawakuchi, University of Texas MD Anderson Cancer Center, Houston, TX
WE-IePD-TRACK 5-3Influence of Sub-Lethal Damage Repair On Biological Effectiveness of Proton with the Consideration of Dose Delivery Time Structure in Scanning Proton Therapy
K Kasamatsu1*, H Hosoi2, S Tanaka3,4, K Miyazaki3, S Takao3,4, N Miyamoto3,4, K Umegaki3, T Hashimoto5, K Nishioka5, S Shimizu4,5, T Matsuura3,4, (1)Hokkaido University, Graduate School of Biomedical Science and Engineering, Sapporo, Japan (2)Hokkaido University, School of Engineering, Sapporo, Japan (3)Hokkaido University, Faculty of Engineering, Sapporo, Japan (4)Hokkaido University Hospital, Department of Medical Physics, Sapporo, Japan (5)Hokkaido University, Faculty of Medicine, Sapporo, Japan
WE-IePD-TRACK 6-5Comparison of Dose Escalation Strategies for Head and Neck Cancer Patients Using a Radiobiological Model of Reoxygenation
M Guerrero1*, E Smith2, (1) University of Maryland School of Medicine, Baltimore, MD, (2) Yale University,

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