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Objectives
1. Set up and Oversee a Radiopharmaceutical Therapy Program.
2. Identify and manage the different safety concerns for the different radiopharmaceuticals
3. Properly set up a phantom and obtain a SPECT camera calibration coefficient for activity quantification.
4. Apply the Medical Internal Radiation Dose (MIRD) methodology.
5. Identify and use Monte Carlo-based RPT dosimetry commercial software.
6. Convert between RPT absorbed dose and 2-Gy fraction equivalent
7. Apply the different approaches for normal organ dosimetry vs. tumor dosimetry.
8. Understand and be able to choose an appropriate curve fitting option
9. Use provided double check and QA tools for a reproducible and robust dosimetry.
Program Outline (subject to change)
| Friday, June 2 | |||
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| 10:00 AM – 5:00 PM | Registration & Housing Check-in | ||
| 6:00 PM – 7:00 PM | Dinner | ||
| 7:30 PM – 9:30 PM | Icebreaker Reception | ||
| Saturday, June 3 | |||
| 7:00 AM – 7:30 AM | Breakfast | ||
| 7:50 AM – 8:00 AM | Welcome, Scope, and Utility of Program |
R. Hobbs V. Narayana |
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| 8:00 AM – 8:35 AM | Current FDA-approved RPT’s and their use | N. Maughan | |
| 8:35 AM – 9:10 AM | Regulatory, Medical Events | K. Tapp | |
| 9:10 AM – 9:45 AM | Physician Perspective | C. Divgi | |
| 9:45 AM – 10:15 AM | Coffee Break | ||
| 10:15 AM – 10:50 AM | Release Criteria vs. Take Home Instructions | W. Bolch | |
| 10:50 AM – 11:25 AM | Receiving and Waste Disposal | J. Clements | |
| 11:25 AM – 12:00 PM | Professional Economics | R. Tarver | |
| 12:00 PM – 1:15 PM | Lunch | ||
| 1:30 PM – 3:00 PM |
Workshops – Part 1 Each attendee will have an opportunity to attend each workshop:
Workshops will continue at 3:30 PM. |
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| 3:00 PM – 3:30 PM | Coffee Break | ||
| 3:30 PM – 5:00 PM | Workshops – Part 2 Each attendee will have an opportunity to attend each workshop:
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| 6:00 PM – 7:00 PM | Dinner | ||
| 7:30 PM – 9:00 PM | Evening Discussion/Social | ||
| Sunday, June 4 | |||
| 7:00 AM – 7:30 AM | Breakfast | ||
| 7:50 AM – 8:00 AM | Previous Day Recap | R. Hobbs V. Narayana |
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| 8:00 AM – 8:50 AM | SPECT/CT Quantification | E. Frey | |
| 8:50 AM – 9:25 AM | PET and Radiopharmaceutical Therapy: Clinical Physics Establishing a Sound Foundation for Quantitative Accuracy | J. Wilson | |
| 9:25 AM – 10:00 AM | PET/CT Quantification | D. Bergeron | |
| 10:00 AM – 10:30 AM | Coffee Break | ||
| 10:30 AM – 11:05 AM | Dose Calibrator QA, Traceability and Uncertainty | D. Bergeron | |
| 11:05 AM – 11:40 AM | Phantom Preparation Calibration/Sensitivity Factor Calculation | E. Frey | |
| 11:40 AM – 12:15 PM | Machine QA – Transitioning to Therapy | S. Graves | |
| 12:30 PM – 1:00 PM | Travel to Target Field via Metro Transit Light Rail (From East Bank Station) Metro Transit Visitor Pass included with Registration |
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| 1:10 PM – 4:10 PM | Minnesota Twins vs. Cleveland Guardians (Target Field) Ticket and Lunch/Concession Stand Voucher included with Registration |
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| 4:30 PM – 5:00 PM | Travel to UMN via Metro Transit Light Rail (From Target Field Station) Metro Transit Visitor Pass included with Registration |
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| 6:00 PM – 7:00 PM | Dinner | ||
| Monday, June 5 | |||
| 7:00 AM – 7:30 AM | Breakfast | ||
| 7:50 AM – 8:00 AM | Previous Day Recap |
R. Hobbs V. Narayana |
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| 8:00 AM – 8:35 AM | Principles of Prospective Treatment Planning |
R. Hobbs J. Steiner |
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| 8:35 AM – 9:10 AM | MIRD Applied: Whole Organ Dosimetry and Phantoms | W. Bolch | |
| 9:10 AM – 9:45 AM | Yttrium-90 Microspheres: Treatment Planning using the MIRD Formalism | D. Alvarez | |
| 9:45 AM – 10:15 AM | Coffee Break | ||
| 10:15 AM – 10:50 AM | Curve Fitting – Time Point and Fit Choices, Extrapolation | J. O’Donoghue | |
| 10:50 AM – 11:25 AM | Uncertainties and Error Propagation | J. Gear | |
| 11:25 AM – 12:00 PM | Surrogate Imaging - Time Points and Decay Correction | A. Kesner | |
| 12:00 PM – 1:15 PM | Lunch | ||
| 1:30 PM – 3:00 PM | S-value-Based Dosimetry Workshops Attendees have an opportunity to attend two of the three: Workshop Options – Part 1
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| 3:00 PM – 3:30 PM | Coffee Break | ||
| 3:30 PM – 5:00 PM | S-value-Based Dosimetry Workshops Attendees have an opportunity to attend two of the three: Workshop Options – Part 2
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| 6:00 PM – 7:00 PM | Dinner, Pioneer Dining Hall | ||
| 7:30 PM – 9:00 PM | Evening Discussion/Social | ||
| Tuesday, June 6 | |||
| 7:00 AM – 7:30 AM | Breakfast | ||
| 7:50 AM – 8:00 AM | Previous Day Recap | R. Hobbs V. Narayana |
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| 8:00 AM – 8:35 AM | Principles of Voxelized Dosimetry | S. Graves | |
| 8:35 AM – 9:10 AM | Registration Choices and 3D Dose Maps | B. Bednarz | |
| 9:10 AM – 9:45 AM | Uncertainties and Relative Merits of Voxelized Dosimetry vs. MIRD Method | J. Gear | |
| 9:45 AM – 10:15 AM | Coffee Break | ||
| 10:15 AM – 10:50 AM | Bio-effect Modeling, Standardization and Applicability, MTD and EBRT Equivalence, Combinations | R. Hobbs | |
| 10:50 AM – 11:25 AM | Standardization and ICRU 96 | R. Howell | |
| 11:25 AM – 12:00 PM | Single-Time-Point Dosimetry: Pros and Cons | Panel Discussion | |
| 12:00 PM – 1:15 PM | Lunch | ||
| 1:30 PM – 3:00 PM | Voxelized Based Dosimetry Workshops Attendees have an opportunity to attend two of the three: Workshop Options – Part 1
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| 3:00 PM – 3:30 PM | Coffee Break | ||
| 3:30 PM – 5:00 PM | Voxelized Based Dosimetry Workshops Attendees have an opportunity to attend two of the three: Workshop Options – Part 2
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| 6:00 PM – 7:00 PM | Dinner | ||
| 7:30 PM – 9:00 PM | Evening Discussion/Social | ||
| Wednesday, June 7 | |||
| 7:00 AM – 7:30 AM | Breakfast, Pioneer Dining Hall | ||
| 7:50 AM – 8:00 AM | Previous Day Recap | R. Hobbs V. Narayana |
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| 8:00 AM – 8:35 AM | Potential Sources of Error: SNMMI Challenge and/or IAEA CRP Results | R. Hobbs | |
| 8:35 AM – 9:10 AM | Double-checks, QA, Intermediate Results and Consistency | R. Barbee | |
| 9:10 AM – 9:40 AM | Coffee Break | ||
| 9:40 AM – 11:30 AM | Workshop: Second Check, QA, Checklist Utilization | ||
| 11:30 AM – 12:00 PM | Closing Statements | R. Hobbs V. Narayana |
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| 12:00 PM | Meeting Adjourns Lunch on Your Own |
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