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Radiation Timing: The Physician & Physicist Perspective

K Huber1*, M Taylor2*, (1) Tufts Medical Center, Boston, MA, (2) Alliance Cancer Care, Huntsville, AL

Presentations

(Saturday, 3/26/2022) 4:30 PM - 5:30 PM [Central Time (GMT-5)]

Room: Celestin D-E

Treatment fractionation can sometimes feel like a black box from the physics perspective, especially as fractionation patterns change over time. Additionally, modification to the treatment schedule such as planned or unplanned breaks, treating over the weekend, or treatment fractions changed during the course of treatment can impact workloads and can leave physicists asking “why?”. The first presentation will utilize challenging “real-life” clinical cases to illustrate how the Radiation Oncologist applies radiobiological principles to guide decisions regarding fractionation and management of unplanned treatment breaks. The second presentation take a physicist perspective and presents practical examples from a community practice on how treatment breaks and previous dose accumulations are addressed and documented.
The audience will learn:
1. The 4 “Rs” of radiobiology and how to apply this concept to clinical decision making for patients with unplanned treatment breaks or altered fractionation.
2. How to apply the linear quadratic model to estimate biologically equivalent doses for various fractionation schemes.
3. How fractionation is used to maximize tumor control and minimize normal tissue toxicity.
4. How cancer biology can affect decision making around fractionation.
5. Effectively using BED calculations for missed treatments
6. Performing dose accumulations with previous treatments

Handouts

Keywords

Radiobiology, Radiation Therapy, RBE

Taxonomy

TH- Radiobiology(RBio)/Biology(Bio): RBio- general

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