Cumulative Dose Evaluation On TSET Patient Fem Using Cherenkov Imaging
Y Zhu1*, W Zhong1, T Miao2, B Pogue3, T Zhu1, (1) University of Pennsylvania, Philadelphia, PA, (2) Yale University, New Heven, CT, (3) Department of Medical Physics, University of Wisconsin-Madison, Madison, WI
Presentations
MO-H345-IePD-F1-1 (Monday, 7/11/2022) 3:45 PM - 4:15 PM [Eastern Time (GMT-4)]
Exhibit Hall | Forum 1
Purpose: In total skin electron therapy (TSET), in-vivo quality assurance of dose homogeneity in patient is challenging because the patient must stand in six different postures. Cherenkov imaging provides a method to evaluate the dose distribution in each posture. However, existing methods require tremendous manpower in the modeling of patient finite-element mesh (fem), hence lacking efficiency when processing multiple patients. This study aims to develop a fast method to generate the whole-body patient fem from the raw 3D surface scans by deformably registration of a template fem for dose projection purposes.
Methods: A semi-automatic method is developed to: (1) Regulate the raw 3D scans of the patient (2) Use the GUI-based Matlab toolbox to deformably register the template fem to the target fem (patient 3D scans) (3) Apply rigging to the deformed resulting fem to match all postures, and (4) Project the Cherenkov imaging converted (or Monte Carlo calculated) dose values onto the patient body fem for dose cumulation.
Results: An extensive toolbox is developed to efficiently perform deformable registration of TSE patient models for dose projections. We have projected the both the Cherenkov converted and MC calculated dose into the patient fems. The cumulative dose can be determined for both Cherenkov converted and MC calculated dose distribution on patient. The differences between Cherenkov and MC dose distribution are evaluated.
Conclusion: Cherenkov imaging provides valuable information about the cumulative dose distribution for TSET. A semi-automatic MATLAB toolbox is developed to more efficiently determine the patient model of different postures for cumulative dose analysis.
Funding Support, Disclosures, and Conflict of Interest: This study is funded by NIH R21 CA239127
Keywords
Total Skin Irradiation, Dose Uniformity, Finite Element Analysis
Taxonomy
IM- Optical : Image Reconstruction
Contact Email