A Preliminary Dosimetry Evaluation Study for the New Treatment Planning System On All-In-One (AIO) of Nasopharyngeal Carcinoma (NPC)
X Yang1*, S Huang1, W Sun1, J Du1, Y Du1, L Lin1, K Zhang2, J Tang2, Y Sun1, X HUANG1, (1) Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, China, (2) United Imaging Healthcare (UIH) Co., Ltd, Shanghai, China
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PO-GePV-T-13 (Sunday, 7/10/2022) [Eastern Time (GMT-4)]
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Purpose: A new-type linear accelerator (having a diagnostic-quality CT scanner compactly fixed behind the gantry of C-arm linac) with its unique treatment planning system (TPS) from United Imaging Healthcare (UIH) was introduced into clinical use in October 2021. To evaluate its plan optimization performance of the new TPS (uRT-TPS), a preliminary dosimetry study was designed, and its results was compared with the Varian Eclipse TPS.
Methods: Fifteen Nasopharyngeal Carcinoma (NPC) patients’ plans were enrolled in this study. These plans were randomly selected from our clinical database. All ROIs, including Target and OARs were delineated following the clinical requirement. The clinical plans in Eclipse system were designed by a senior dosimetrist with more than 8-year experience. The uRT-TPS has developed an All-in-One (AIO) auto-plan function, which is able to optimize plans automatically from clinical goals. This function was tested in this work and compared with manual plans. There is no dose normalization of the target volume coverage for the comparison among the three plans.
Results: Both kinds of the plans were clinical acceptable. The mean optimization time of AIO plans was 5.6 mins. For the manual plans and the AIO plans, statistically significant difference was found in the PTVnx prescription coverage (total dose 69.96Gy with 33fractions), which was 98.7%±1.5% and 96.8%±1.6%, and the SpinalCord D0.3cc, which was 34.6±2.8Gy and 30.3±7.4Gy, respectively. There is no significant difference in D0.3cc of brainstem/temporal lobes/optical nerves/eyes/lens and Dmean of parotids (L/R), submandibular glands (L/R), and oral cavity. However, for challenging cases where BrainStem partially overlapped with PTVnx, manual plans showed better control of hotspot volume.
Conclusion: AIO auto-plan of UIH TPS has provided a similarly performance with the eclipse manual plans while significantly shortening the treatment planning time to couple minutes. And it AIO function performance will be required to be analyzed in more scenarios.
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