Epicardial Fat: Evaluating Measurement Methodology of An Imaging Biomarker
G Clarke1*, A Moody2, J Curran3, J Blangero4, (1) UT Health San Antonio, San Antonio, TX, (2) University of Texas Health Science Center - San Antonio, San Antonio, TX, (3) University Of Texas Rio Grande Valley,(4) Ut Rio Grande Valley,
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PO-GePV-I-36 (Sunday, 7/10/2022) [Eastern Time (GMT-4)]
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Purpose: Pericardial adipose tissue the mediastinum, associated with metabolic syndrome and coronary artery disease, is found in two compartments: (i) epicardial adipose tissue (EAT), deposited between the epicardium and pericardium and (ii) paracardial adipose tissue (PAT), deposited on the external surface of the pericardium. MRI is commonly used to measure EAT and PAT, but no method has been standardized. This study evaluates the hypothesis that EAT and PAT measurements in short axis (SA) and long-axis (LA) slices are equivalent.
Methods: 16 subjects (age:57±13 years, 9M/7F) enrolled in a large genetic study were examined on a 3T scanner. Pericardial fat scans were obtained in diastole using SA and LA, using a IR-SFFP sequence (TR/TE=2.4/1.1 ms, slice=8.5 mm,1.3x1.3 mm pixel, flip angle=50o) covering the left ventricle (LV) in a single breath-hold. The MANGO image analysis package (https://ric.uthscsa.edu/mango) was used to measure pericardial fat. Using long axis, 4-chamber images, thickness of LA pericardial fat was measured from the cardiac mid-ventricular level laterally and SA from the mitral valve plane to the apex axially). For EAT and PAT volumes, the area subtended by the manual tracings was determined in each slice and multiplied by the slice thickness to yield the fat volume. Data from LA and SA acquisitions were evaluated using Pearson correlation to compare interstudy.
Results: Both EAT and PAT volumes measured in SA and LA views were significantly correlated (r=0.88, r=0.82, p<0.01). The amount of EAT vs PAT measured were also significantly correlated in both the SA and LA views (r=0.88, r=0.79, p<0.01). Both EAT and PAT volumes measured in SA and LA views were significantly correlated with BMI (r=0.51, r=0.55, p<0.05).
Conclusion: Results suggest that measurement of epicardial fat by MRI is independent of the orientation of the imaging slice with respect to the heart.
Funding Support, Disclosures, and Conflict of Interest: NIH/OD P51OD011133, NIH/NIA U19AG057758, NIH/NIMHD R01MD012564
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