Electroacoustic Tomography for the Guidance of Electroporation
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PO-GePV-M-74 (Sunday, 7/10/2022) [Eastern Time (GMT-4)]
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Purpose: Electroporation is a clinical electrotherapy technique that uses the local application of short, strong electrical pulses to deliver drugs to the target area or to directly induce tumor cell apoptosis. Since the size, location, shape and tissue environment of the treated target varies, it is necessary to monitor the distribution of the electric field in real time. The lack of methods to directly visualize the electric field distribution has limited its clinical application. We demonstrate for the first time the acoustic signal induced by electric fields and its potential for real-time, in situ electrotherapy monitoring.
Methods: Measurement of acoustic signals induced by pulsed electric fields for real-time electrotherapy monitoring. The pulsed electric field causes a transient and localized temperature rise, which results in detectable acoustic waves in the ultrasound system due to thermoelastic expansion. This is referred to as the electroacoustic effect. We used a nanosecond pulse generator to induce the electroacoustic signal and a single transducer and ring array of ultrasound transducers to receive the signals.
Results: Pulsed electric field-induced acoustic waves were measured at different electric field voltages. The relationship between the electroacoustic signal strength and the applied voltage has been tested and quantified. Moreover, different concentrations of sodium chloride has been tested within agar phantoms. Finally, the electric field distribution has been imaged with EAT in real-time in chicken breast tissue.
Conclusion: The high-resolution EAT images can be directly used for real-time monitoring electrotherapy in situ and has potential for translation in clinical applications.
Funding Support, Disclosures, and Conflict of Interest: This work was supported by the National Institute of Health (R37CA240806), American Cancer Society (133697 RSG 19 110 01 CCE). The authors would like to acknowledge the support from UCI Chao Family Comprehensive Cancer Center (P30CA062203)
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