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Session: The SNMMI Lu-177 Dosimetry Global Challenge: Results and Conclusions [Return to Session]

The SNMMI Lu-177 Dosimetry Global Challenge: Results and Conclusions

Y Dewaraja1*, R Danieli2*, W Erwin3*, C Uribe4*, (1) University of Michigan, Ann Arbor, MI, (2) Institut Jules Bordet, Brussels, BE, (3) UT MD Anderson Cancer Center, Houston, TX, (4) BC Cancer Research Institute, Vancouver, BC


TU-H-202-0 (Tuesday, 7/12/2022) 2:45 PM - 3:45 PM [Eastern Time (GMT-4)]

Room 202

The Dosimetry task Force of the Society of Nuclear Medicine and Molecular Imaging (SNMMI) launched the Lu-177 Dosimetry Challenge in 2021. The goal was to collect data from the global nuclear medicine community to understand and characterize the variability associated with performing dose calculations in radiopharmaceutical therapy (RPT). Serial planar and quantitative SPECT/CT imaging data from 2 patients who underwent Lu-177 DOTATATE RPT were anonymized and shared with participants via a digital data repository housed at the University of Michigan. The Challenge consisted of 5 different and independent tasks that included planar, hybrid planar/SPECT and SPECT/CT-only imaging-based organ and tumor dosimetry. This session will include discussion on how the Challenge data were generated and shared, and will further include presentations from two participants summarizing their approach to the dosimetry tasks. An overview of the different approaches for segmentation, dosimetry methods utilized, and the software used by the over 280 submissions from 18 different countries will be given. The session will focus on the presentation of the analysis of the submitted dosimetry results, and will include descriptive statistics for each of the 5 tasks. The variability in absorbed dose estimates associated with different steps along the dosimetric analysis chain such as segmentation, time-integrated activity determination and dose calculation (obtained from the analysis of the 5 Challenge Tasks) will be discussed, and common mistakes will be revealed. The session will conclude with a panel discussion on how the dataset from the Challenge can facilitate efforts to standardize and harmonize dosimetry methods to reduce variability in calculated dose. The session is relevant to those who wish to become familiar with options available for performing internal dosimetry as well as to experts and RPT practitioners to expand their awareness of variability associated with dose estimation.

Learning Objectives
1.Understand what imaging and other data are needed to perform image-based, patient-specific dosimetry in radiopharmaceutical therapy
2.Become familiar with different methods for performing dosimetry and understand how to do basic dosimetry calculations
3.Understand the level of variability associated with calculated absorbed doses
4.Understand the need for standardization of RPT dosimetry and its role in clinical implementation of dosimetry guided treatment planning

Funding Support, Disclosures, and Conflict of Interest: Consultant for MIM Software



Not Applicable / None Entered.


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