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Keywords: radiobiology
MO-FG-BRB-3Combining Monte Carlo Voxel-Level External Beam Radiotherapy and Iodine-131 SPECT Based Radiopharmaceutical Therapy Dosimetry Using Deformable Registration and Radiobiological Quantities
D Adam*, J Grudzinski, P Hill, T Bradshaw, S Cho, A Burr, P Harari, B Bednarz, University of Wisconsin, Madison, WI
MO-I430-BReP-F2-4Quantification of Gold Nanoparticle Radiosensitization On Prostate Cancer Combining Monte Carlo Simulations and the Local Effect Model
R Schmidt*, D Hara, N Dogan, J Shi, A Pollack, J Ford, University of Miami, Miami, FL
MO-I430-BReP-F3-5To Establish Correlation Between Physical Microdosimetric Quantities Such as Dose Mean Lineal Energy, Target Size and Biological Endpoints Such as DNA Double Strand Breaks in HeLa Cells Irradiated with Iridium-192 High Dose Rate Brachytherapy Source and 225kV X-Rays
S Dev1*, B Behmand2, P Pater3, S Abbasinejad Enger4, (1) McGill University, Montreal, QC, CA, (2) University of McGill, Montreal, QC, CA, (3) McGill University Health Centre, Montreal, QC, CA, (4) Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, QC, CA
PO-GePV-M-313Quantitative Modeling On Tissue-Specific Stem Cell Amounts for Radiation Induced Normal Tissue Complications
K Wang*, M Huq, UPMC Hillman Cancer Center and University of Pittsburgh School of Medicine, Pittsburgh, PA
PO-GePV-T-75Monte Carlo Investigation of Planar Electron Mimbeams Created by a Single Halbach Cylinder
GA McAuley*, JD Slater, Department of Radiation Medicine, Loma Linda University, Loma Linda, CA
PO-GePV-T-96Clinical Assessment of Commercially Available Software for Composite Hypofractionated Treatment Plans
C Esquivel, T Roberts, A Tipton, O Calvo*, L Patton, Texas Oncology, San Antonio, San Antonio, TX
PO-GePV-T-127An Exploration Toward the Superior Hyperfractionated Schedule in the Intensity Modulated Proton Therapy for Pharyngeal Cancer Under the Variable Relative Biological Effectiveness
K Kasamatsu1*, T Matsuura2,3, K Yasuda4, K Miyazaki2,3, S Takao2,3, H Aoyama4, (1)Graduate School of Biomedical Science and Engineering, Hokkaido University, Sapporo, JP (2)Faculty of Engineering, Hokkaido University, Sapporo, JP (3)Department of Medical Physics, Hokkaido University Hospital, Sapporo, JP (4)Faculty of Medicine, Hokkaido University, Sapporo, JP
PO-GePV-T-215A Practical Workflow to Determine Patient-Specific Critical Organ Dose Constraints Considering Organ-Specific Radiobiological Effect for Reirradiation Planning
A Tai*, E Quashie, K Kainz, E Paulson, E Gore, J Bovi, M Awan, M Straza, X Li, Medical College of Wisconsin, Milwaukee, WI
PO-GePV-T-220A Transportable Hypoxic Phantom for DNA Irradiation Damage Studies
D Johnson*, M Tambasco, San Diego State Univ, San Diego, CA
PO-GePV-T-439Applying Optical Reporters of Radiation Damage to Ex Vivo Tissue Models
W Thomas1*, J Sunnerberg2, M Reed1, B Pogue1,2, (1) University of Wisconsin-Madison, Madison, WI, (2) Dartmouth College, Hanover, NH
PO-GePV-T-440Dosimetry Equivalence Between X-Ray and Gamma-Ray Irradiation with Validated Monte Carlo Simulations
J Caravaca Rodriguez1, R Peter2*, J Yang3, J Camara Serrano1, C Nostrand4, V Steri1, C Gunther4, Y Seo1, (1) University of California San Francisco, (2) University of California Berkeley, (3) UT Southwestern Medical Center, Texas, (4) C&C Irradiator Service, LLC
PO-GePV-T-443Commissioning of a Commercial Orthovoltage Small-Animal and Cell Irradiator
J Van Schelt*, K Jones, B David, Y Liao, E Blazek, Rush University Medical Center, Chicago, IL
PO-GePV-T-446A Simulation Study On the Radiation-Induced Immune-Response of Tumor After Radiosurgery Using An Improved Cellular Automata Model
D Kawahara1*, Y Nagata1, Y Watanabe2, (1) Department of Radiation Oncology, Hiroshima University, Hiroshima, Hiroshima, Japan, (2) University of Minnesota, Minneapolis, MN
PO-GePV-T-447Computational Modelling of Impedance Based Cell Migration for Improved Chemotherapy and Radiotherapy
M Schwengler*, B Ibironke, K Lemke, A Walther, A Ekpenyong, Creighton University, Omaha, NE
SU-K-206-1A High-Performance Computational Framework to Simulate Biological Effects of Radiation Exposure as a Function of Chromosome Structure
M Andriotty1,2*, J Gounley1, C Wang2, A Kapadia1, G Agasthya1, (1) Advanced Computing for Health Science, Oak Ridge National Laboratory, Oak Ridge, TN, (2) Georgia Institute of Technology, Atlanta, GA
SU-K-206-5High Throughput Alpha Particle Irradiator for Radiobiology Research
D Martinus1*, D Flint1, S Bright1, M Khuroo2, S Prajapati1, S Shaitelman1, G Sawakuchi1, (1) UT MD Anderson Cancer Center, Houston, TX, (2) Rice University, Houston, TX
SU-K-206-6Is the Radiosensitizing Effect of Platinum Nanoparticles in Proton Irradiation Due to An Enhanced Proton Energy Deposition?
C Behrends1,2,3*, C Baecker1,2,3, I Schilling2, S Zwiehoff4, J Weingarten2, K Kroeninger2, C Rehbock4, S Barcikowski4, J Wulff1,3, C Baeumer1,2,3,5, B Timmermann1,3,5,6,7, (1) West German Proton Therapy Centre Essen, Essen, DE, (2) TU Dortmund University, Department of Physics, Dortmund, DE, (3) University Hospital Essen, West German Cancer Centre, Essen, DE, (4) University of Duisburg Essen, Technical Chemistry I, Essen, DE, (5) German Cancer Consortium, Heidelberg, DE, (6) University of Duisburg Essen, Faculty of Medicine, Essen, DE, (7) University Hospital Essen, Department of Particle Therapy, Essen, DE
TH-A-206-5Towards Finding the Right Liver Vasculature Model for Estimating Dose to Circulating Blood During Radiotherapy in Hepatocellular Carcinoma Patients
S Xing1,2*, C Correa Alfonso3, J Shin4, J Pursley1,2, N Depauw1,2, L McCullum1,2, S Domal3, J Withrow3, W Bolch3, C Grassberger1,2, H Paganetti1,2, (1) Harvard Medical School, Boston, MA, (2) Massachusetts General Hospital, Boston, MA, (3) University of Florida, Gainesville, FL, (4)National Cancer Institute, Rockville, MD
TH-D-BRC-3Dynamic Brain Blood Flow Modeling Using Detailed Vasculature to Investigate Lymphocyte Depletion During External Beam Radiotherapy
L McCullum1*, S Xing1, J Shin2, C Beekman1, C Correa Alfonso3, S Domal3, J Withrow3, W Bolch3, H Shih1, H Paganetti1, C Grassberger1, (1) Massachusetts General Hospital / Harvard Medical School, Boston, MA (2) National Cancer Institute, Bethesda, MD, (3) University of Florida, Gainesville, FL
TU-D1030-IePD-F7-2Expanding Microdosimetry to Include Indirect Damage Induced by Protons and Alpha Particles
A Bertolet*, G Tamborino, H Paganetti, J Schuemann, Department of Radiation Oncology, Massachusetts General Hospital, Boston, MA
TU-D930-IePD-F3-3Dosimetric Comparison of Small Animal Intensity-Modulated Versus 3D Conformal Radiotherapy Using a Computer-Generated Cardiac Mouse Phantom
J Slagowski1*, E Pearson2, G Redler3, D Olivera Velarde2, H Halpern2, R Tummala2, B Aydogan2, (1) University of Wisconsin - Madison, Madison, WI, (2) University of Chicago, Chicago, IL, (3) H. Lee Moffitt Cancer Center, Tampa, FL
TU-D930-IePD-F3-4Modeling Differential Tumor and Normal-Tissue Response of FLASH-RT Via Radiolytic Oxygen Depletion and Reactive Oxygen Species
J Ma1*, M Tang1, H Gao2, (1) Shanghai Jiao Tong University, Shanghai, China (2) University of Kansas Medical Center, Kansas City, KS
WE-A-202-1Assessing the DNA Damaging Effectiveness of Ionizing Radiation Using Plasmid DNA
Y Maayah1*, H Nusrat2, G Pang2, M Tambasco1, (1) San Diego State Univ, San Diego, CA, (2) Odette Cancer Centre, Toronto, ON, CA
WE-A-202-4Intra- and Inter-DNA Dosimeter Measurement Variability for Quantifying DNA Double Strand Breaks From Ionizing Radiation
C Valdes*, M Tambasco, San Diego State Univ, San Diego, CA
WE-B-BRC-13D Organoids as a Model to Study and Predict the Response of Pancreatic Cancer to Radiation Therapy
J Polf*, H Shukla, T Dukic, S Roy, B Bhandary, N Lamichhane, University of Maryland School of Medicine, Baltimore, MD
WE-F-206-2FLASH Irradiation of Drosophila Melanogaster Using Low Energy X-Rays
A Hart*, J Dudzic, J Eby, S Perlman, M Bazalova-Carter, University of Victoria, Victoria, BCCA,
WE-F-206-5Quantifying Reactive Species and Oxygen Consumed in FLASH Radiotherapy in Vitro to Assess Mechanisms of Tissue Damage Reduction
J Sunnerberg1*, A Petusseau1, M Rahman1, X Cao1, P Bruza1, S Vinogradov2, B Pogue1,3, (1) Dartmouth College, Hanover, NH, (2) University Of Pennsylvania, Philadelphia, PA (3) University of Wisconsin-Madison, Madison, WI
WE-F-206-6Radiobiological Effects of Ultra-High FLASH Dose Rate Using X-Rays Generated by the Small Animal Radiation Research Platform
D Goia*, K Shoniyozov, A Velalopoulou, I Verginadis, M Kim, E Diffenderfer, L Dong, C Koumenis, University of Pennsylvania, Philadelphia, PA